A Word to Physicians

Comprehensive Clinical Collaboration Guide with PharOmics

This page is designed as a complete reference for healthcare providers, diagnostic laboratories, clinics, and medical specialists to familiarize themselves with PharOmics' scientific process and technological backbone.

Why PharOmics?

Operating as the bridge between advanced genomics and clinical application in the Middle East, PharOmics functions through two main approaches:

Clinical & Professional Sector (B2B): Providing specialized sequencing and genomic analysis services for physicians, pharmacists, hospitals, and specialized centers.

Direct-to-Consumer Sector (B2C): Offering home-use kits based on microarray technology to enhance individuals' lifestyle health and raise public awareness.

On this page, we focus on the professional and clinical workflow.

Step One: Understanding the Need and Selecting the Method (Clinical Expertise)

Choosing the right method is the foundation of a successful genomic analysis. Leveraging specialized knowledge, PharOmics helps you select the best approach:

Next-Generation Sequencing (NGS) for Pharmacogenetics and Diagnostics: Today, NGS is well-established as a powerful and accurate method for detecting chromosomal abnormalities and gene mutations in clinical settings. This approach is particularly critical in pharmacogenetics. 97% of people carry at least one genetic variant that affects their response to medications, and preemptive testing can personalize therapy while preventing adverse reactions.

Microarray (SNP Array) for Direct-to-Consumer Kits: This technology is optimal for examining hundreds of thousands of genetic markers associated with non-clinical traits (e.g., fitness, nutrition, artistic and academic aptitudes) and is recognized as a cost-effective alternative to NGS for specific applications. In certain cases, the accuracy of microarrays in detecting genomic deletions can even surpass that of other methods.

Step Two: Step‑by‑Step Process for Clinical Genomic Testing 

This section outlines the complete cycle of a clinical request from partner centers:

1. Request and Informed Consent:

   Based on the patient's condition and following international guidelines (such as those from the CPIC – Clinical Pharmacogenetics Implementation Consortium**), the ordering physician prescribes the test.

   Partner laboratories and centers complete the patient information form and the Informed Consent document, then submit them to PharOmics.

2. Sample Collection and Shipping:

   - Clinical samples are primarily collected as peripheral blood (in EDTA tubes) or buccal swabs.

   - Custom sampling kits (including full instructions) are provided by PharOmics to the centers.

   - Collected samples, along with the completed forms, are sent via reputable international courier services to PharOmics' partner laboratory abroad.

3. Laboratory Analysis (at the International Partner Lab):

   - DNA Extraction: Genomic DNA is isolated from the sample.

   - Library Preparation: For sequencing, gene libraries are constructed using standard kits.

   - Sequencing: Next‑Generation Sequencing is performed on advanced platforms such as the Illumina NovaSeq.

   - Data Processing: Raw data are mapped to a reference genome (e.g., hg19) using validated algorithms, and variants are identified with analytical software packages.

4. Clinical Interpretation and Reporting (by PharOmics' Expert Team):

   This is the most critical and specialized step in PharOmics' workflow. The raw data are interpreted and classified by our team of analysts and geneticists, utilizing globally recognized databases and following the American College of Medical Genetics and Genomics (ACMG) guidelines.

   The final report is fully personalized, provided in both English and the local language, tailored to the target population (with a focus on Middle Eastern demographics), and compatible with Electronic Health Records (EHR). This report includes evidence‑based clinical recommendations, akin to CPIC guidelines, for drug dosing or alternative therapy selection.

Dear Colleague,

Today, precision medicine is no longer a distant vision—it is a reality that increasingly plays a pivotal role in our daily clinical decision-making. As a specialist physician, you understand well that each patient's response to a given medication is unique, and these differences are rooted in their genetic blueprint.

PharOmics, serving as the bridge between advanced genomics and clinical practice, stands alongside you to make this path smoother and more precise.

Why should you consider partnering with PharOmics?

1. Reducing Adverse Effects and Treatment Failures:
   By utilizing pharmacogenetic (PGx) testing based on Next-Generation Sequencing (NGS), you can select the most effective drug and optimal dosage for your patient before prescribing—helping to prevent serious adverse reactions or suboptimal responses. This translates to safer, more effective, and truly personalized therapy for every patient.
2. Adherence to International Standards and Scientific Rigor:
   Our analysis and interpretation processes are fully aligned with the latest globally recognized guidelines, including the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines and the American College of Medical Genetics and Genomics (ACMG) recommendations. As a result, our reports are not only defensible but also empower you to make evidence-based decisions that reflect the most current scientific knowledge.
3. Tailored, Clinically Actionable Reports:
   We recognize that in your practice and hospital settings, time is your most valuable asset. That is why our final reports are designed to be concise, practical, and fully personalized—delivered in a format directly compatible with your Electronic Health Record (EHR) There is no need to spend time deciphering raw data; you will have immediate access to clear, actionable clinical recommendations for drug dosing or therapeutic alternatives.
4. An Opportunity to Be a Pioneer in Iran and the Region:
   By partnering with PharOmics, you join a growing community of forward-thinking physicians who are leading the charge in personalized medicine across the Middle East. This collaboration not only enhances treatment precision and strengthens patient trust but also elevates your own scientific and professional standing.

Join us in moving beyond trial-and-error prescribing and into the era of precision medicine. The scientific and support team at PharOmics is always here to ensure the best possible experience for you and your patients.